DNA polymerases that produce a faithful copy the genome every time a cell divides have two functional domains: a polymerase domain that takes care of incorporating the correct DNA building blocks (nucleotides), and a proofreading domain that takes care of removing any mis-incorporated and mis-matched nucleotide when this, rarely, occurs. Sequencing of colorectal cancers and,
Continue reading DNA polymerase ε and mutagenesis
A first glance at aneuploidy in the YKOC dataset
When sequencing whole genomes, the primary information obtained is the actual DNA sequence, but modern sequencing techniques carry embedded much more information. One of these is the relative abundance of sequencing reads that can be used to estimate the ploidy of each portion of the genome. In haploid yeast cells—the kind used in everyday experiments—each chromosome is
Continue reading A first glance at aneuploidy in the YKOC dataset
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